The EGFR D761 mutation is associated with acquired resistance to EGFR-TKIs (Balak et al., 2006). The functional significance of this alteration is being investigated.
Balak et al Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006 Nov 1;12(21):6494-501
Pao et al..Rational, biologically based treatment of EGFR-mutant nonsmall-cell lung cancer. Nat Rev Cancer. 2010 November ; 10(11): 760–774