Gene | BRAF |
Variant | missense |
Amino Acid Change | D594E |
Transcript ID (GRCh37/hg19) | ENST00000288602 |
Codon(s) | 594 |
Exon(s) | 15 |
Germline/Somatic? | Somatic |
Tumor Type | Primary Site |
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The D594E mutation in BRAF is believed to result in inactivation of BRAF and, therefore, BRAF inhibitors are not likely to be effective.